INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Electrolytic Ablation Dose Planning Methodology
E. LUJÁN; H. SCHINCA; N. OLAIZ; S. URQUIZA; F. V. MOLINA; P. TURJANSKI; G. MARSHALL
Congreso; 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies; 2015
Electrolityc ablation (EA), a medical treatmentincreasingly used in solid tumor ablation, consists in thepassage of a low direct electric current through two or moreelectrodes inserted in the tissue thus inducing pH fronts thatdestroys the tumor. The combined use of EA with a recentlyintroduced one-probe two electrode device (OPTED) results ina minimally invasive tissue ablation technique. Despite itssuccess related to low cost and minimum side effects, EA hasdrawbacks such as the difficulty in determining the currentand time needed to assure total tumor ablation while avoidinghealthy tissue intrusion. Here we introduce a realistic doseplanning methodology in terms of the Coulomb dosageadministered and the associated pH tracking, that predicts anoptimal EA/OPTED protocol treatment for a given tumor size,that is, the current and exposition time necessary to succeed ineliminating all the tumor mass while minimizing healthy tissuedamage.