Synthesis of novel water-soluble chiral ligands based on aryl aldehydes and aminoacids

OLGA SANCHEZ; ANA FOI; FLORENCIA DI SALVO

Chacomus, Buenos Aires

Congreso; IV Latin American Meeting on Biological Inorganic Chemistry - V WOQUIBIO; 2014

The design of new molecules displaying biological activity has been investigated for a long time.1 For instance, inorganic compounds, like platinum complexes, present antitumoral activity and many ligands have been developed to increase such behavior.2 The presence of suitable ligands will provide useful physical properties such as, solubility in water, increased membrane permeability and thus, higher biological activity.3 Additionally, molecular chirality has an important role, as well. In living organisms practically all bioactive molecules such as, proteins and enzymes are chiral and exist in only one enantiomeric form. Consequently, the S and R enantiomers of a chiral compound will exhibit different physiological effects in the human body because they interact in a distinctive way with enzymes and proteins.4 As a result, the choice of appropriate ligands in metal complexes has a decisive role in order to alter and fine tune the biological properties. Based on these considerations, two novel water-soluble chiral ligands have been synthesized from aryl aldehydes via imine condensation with L-tyrosine and L-aspartic acid respectively. In order to get a better understanding of their properties, we are focused also, on studying their coordination chemistry properties using different oligometals like zinc, cobalt and copper