INQUIMAE   12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Coordination Chemistry of Hydroxyurea on Cyanoferrates
Autor/es:
ANDREA MONTENEGRO,† SARA E. BARI,† JOSE A. OLABE,† MARIA M. GUTIERREZ,§ AND VALENTÍN T. AMOREBIETA§
Lugar:
Fortaleza, Brasil
Reunión:
Congreso; XIII Brazilian Meeting on Inorganic Chemistry; 2006
Institución organizadora:
Sociedade Brasileira de Quimica - SBQ
Resumen:
Coordination Chemistry of Hydroxyurea on Cyanoferrates Andrea Montenegro,† Sara E. Bari,† Jose A. Olabe,† Maria M. Gutierrez,§ and Valentín T. Amorebieta§ †Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, FCEyN, UBA, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina and §Departamento de Química, FCE, UMdP, Mar del Plata, B7602AYL, Argentina. e-mail: olabe@qi.fcen.uba.ar pentacyanoferrates, hydroxyurea, C-nitroso compounds   We explore the coordination of hydroxyurea (HU) on the [FeII(CN)5H2O]3- or [FeIII(CN)5H2O]2- ions. HU forms a red compound by reacting with the Fe(III) complex, or with the Fe(II) one in aerated medium, with lmax=468nm; e=3000M-1cm-1. Isolation of a solid allowed its tentative characterization as a C-nitroso derivative, Na3[FeII(CN)5H2NCONO].2H2O, supported by chemical analysis and FTIR spectroscopy. Uncontrolled reaction conditions lead to the formation of sodium nitroprusside, Na2[Fe(CN)5NO].2H2O (NP), probably as a final product of oxidation. EPR measurements in solution showed a stable triplet signal, assignable to [Fe(CN)5NO·]3- as a probable intermediate in the formation of NP. These preliminary results channel our work to gain a mechanistic insight into how transition metal ions are able to bind HU and promote its oxidative reactivity, in the context of the presence of potential biochemical targets.
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