Is Azanone Endogenously Produced in Mammals?

MARTI, M.; DOCTOROVICH, F.; FARMER, P.

The Chemistry and Biology of Nitroxyl (HNO)

Elsevier

Año: 2016; p. 337 - 351

Nitric oxide was the first small reactive molecule shown to be produced in vivounder particular circumstances to act as a signaling agent, as evidenced by the presence of a specific physiological response. Its discovery was later followed by the recognition of other endogenously generated small molecule species that in principle could also act as signaling agents, namely carbon monoxide (CO) and hydrogen sulfide (H2S) among others.1 These small agents changed the paradigm in cell signaling and opened up a whole new world of bioinorganic chemistry and pharmacology. Although HNO has been shown to have relevant pharmacologicalproperties,26 the question of whether it actually can be considered, or not, aspecific signaling molecule, i.e., produced in vivo under given circumstances and with a certain purpose, is still a matter of debate.1,7,8 Key for answering this interrogation is an understanding of how, when, and where HNO can be endogenously (i.e., not derived from an HNO-releasing molecule) produced.