INQUIMAE   12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
capítulos de libros
Título:
How to find an HNO needle in a (bio)-chemical Haystack
Autor/es:
FABIO DOCTOROVICH; DAMIAN BIKIEL; JUAN PELLEGRINO; SEBASTIAN SUAREZ; MARCELO MARTI
Libro:
Progress in Inorganic Chemistry
Editorial:
Wiley
Referencias:
Año: 2014; p. 145 - 148
Resumen:
Azanone (also called nitroxyl or simply HNO) is a highly reactive compound with very interesting chemical properties, and whose role in several chemical and biochemical reactions has not been completely elucidated so far. Its high reactivity, mainly towards itself, originates its intrinsic elusive nature. After a bit more of a decade of intense research, many HNO donors, reactions in which HNO is a reactive intermediate, and azanone biological effects have been described. HNO donors are based on: hydroxylamine and its derivatives, NONOates, and C-nitroso compounds. Nitroxyl has been found as an intermediate in many reactions, most of them involving hydroxylamine oxidation (from -1 to +1 oxidation state) or nitric oxide reduction (from +2 to +1 oxidation state). However, to fully understand the role played by azanone as a reaction intermediate during chemical reactions or as a potential in-vivo (or endogenously) produced metabolite, unequivocal, efficient and easy HNO detection is required. Research towards this goal has been steadily moved forward, exploring a diverse set of trapping and detection strategies. Although many of these have promising perspectives to become the method of choice or benchmark for azanone detection and quantification, their response in a wider variety of conditions including lower and higher putative azanone concentrations, presence of potential interfering agents, competition with HNO sink reactions is still in demand.