INQUIMAE 12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
Discussing Endogenous NO/HNO Interconversion Aided by Phenolic Drugs and Vitamins
Autor/es:
HAMER, MARIANA; SUAREZ, S; NEUMAN, N; ÁLVAREZ, LUCÍA; MUÑOZ, MARTINA; MARTI, MARCELO; DOCTOROVICH, FABIO
Revista:
INORGANIC CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2015
ISSN:
0020-1669
Resumen:
The reduction of NO? to HNO/NO? under biologically compatible conditions has always been thought as unlikely, mostly because of the negative reduction potential: E°(NO?,H+/HNO) = −0.55 V vs NHE at physiological pH. The reaction of NO? with aromatic alcohols (or diols), many of which are biologically relevant, produces HNO, which is emerging as an endogenously produced messenger that mediates specific physiological responses, many of which were attributed to direct NO? effects. What are the most likely physio/pathological conditions for NO?-to-HNO conversion to take place? Which effects usually attributed to NO? are indeed mediated by HNO?
