INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
Discussing Endogenous NO/HNO Interconversion Aided by Phenolic Drugs and Vitamins
HAMER, MARIANA; SUAREZ, S; NEUMAN, N; ÁLVAREZ, LUCÍA; MUÑOZ, MARTINA; MARTI, MARCELO; DOCTOROVICH, FABIO
AMER CHEMICAL SOC
Lugar: Washington; Año: 2015
The reduction of NO? to HNO/NO? under biologically compatible conditions has always been thought as unlikely, mostly because of the negative reduction potential: E°(NO?,H+/HNO) = −0.55 V vs NHE at physiological pH. The reaction of NO? with aromatic alcohols (or diols), many of which are biologically relevant, produces HNO, which is emerging as an endogenously produced messenger that mediates specific physiological responses, many of which were attributed to direct NO? effects. What are the most likely physio/pathological conditions for NO?-to-HNO conversion to take place? Which effects usually attributed to NO? are indeed mediated by HNO?