INQUIMAE   12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
Mass transport effect of mesoscopic domains in the amperometric response of an electroactive species: Modeling for its applications in biomolecule detection
Autor/es:
GRACIELA GONZÁLEZ; GRACIELA PRIANO; MAURICIO GÜNTHER; FERNANDO BATTAGLINI
Revista:
SENSORS AND ACTUATORS B-CHEMICAL
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2008 p. 1 - 1
ISSN:
0925-4005
Resumen:
We report the numerical simulation of an electrochemical system compromising a mesoporous material placed at a close distance of a working electrode. The effect of mesoscopic domains to the amperometric response of an electroactive species by applying a cyclic voltammetry is simulated to establish the influence of different parameters on the sensitivity of this system to detect molecules able to block the pores. Alumina membranes were chosen as mesoporous material; they were modified with anti-horseradish peroxidase as model system to test the behavior predicted by the simulation. The label-free assembled electrochemical system shows a reproducible behavior and it is able to detect a 10 nM protein concentration.