INQUIMAE 12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c,
Autor/es:
CAPDEVILA, D.; ALVAREZ PAGGI, D.; CASTRO, M.A.; TORTORA, V.; DEMICHELI, V.; ESTRIN, D.A.; RADI, R.; MURGIDA, D.H.
Revista:
CHEMICAL COMMUNICATIONS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: Cambridge; Año: 2014 vol. 50 p. 2592 - 2594
ISSN:
1359-7345
Resumen:
Here we report a spectroscopic, electrochemical and computa-tional study of cytochrome c showing that nitration of Tyr74induces Tyr deprotonation, which is coupled to Met/Lys axial ligandexchange, and results in concomitant gain of peroxidatic activity atphysiological pH.
