INQUIMAE 12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release
Autor/es:
MARÍA C. GUTIÉRREZ; ZAIRA Y. GARCÍA-CARVAJAL; MATÍAS JOBBÁGY; FAUSTO RUBIO; LUIS YUSTE; FERNANDO ROJO; MARÍA L. FERRER; FRANCISCO DEL MONTE
Revista:
ADVANCED FUNCTIONAL MATERIALS
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Lugar: WEINHEIM, GERMANY ; Año: 2007 p. 3505 - 3513
ISSN:
1616-301X
Resumen:
Poly(vinyl alcohol) (PVA) scaffolds are prepared by a cryogenic process that consists of the unidirectional freezing of a PVA solution. The scaffolds exhibit a microchanneled structure, the morphology of which (in terms of pore diameter, surface area, and thickness of matter accumulated between adjacent microchannels) can be finely tailored by the averaged molecular weight of PVA, the PVA concentration in the solution, and the freezing rate of the PVA solution. The resulting PVA scaffolds are suitable substrates for drug-delivery purposes, the drug release being controlled (from tens of minutes up to several days) by the morphology of the microchanneled structure. In vitro experiments reveal the efficiency of PVA scaffolds for controlling the release of ciprofloxacin into a bacteria culture medium.
