INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release
MARÍA C. GUTIÉRREZ; ZAIRA Y. GARCÍA-CARVAJAL; MATÍAS JOBBÁGY; FAUSTO RUBIO; LUIS YUSTE; FERNANDO ROJO; MARÍA L. FERRER; FRANCISCO DEL MONTE
ADVANCED FUNCTIONAL MATERIALS
WILEY-V C H VERLAG GMBH
Lugar: WEINHEIM, GERMANY ; Año: 2007 p. 3505 - 3505
Poly(vinyl alcohol) (PVA) scaffolds are prepared by a cryogenic process that consists of the unidirectional freezing of a PVA solution. The scaffolds exhibit a microchanneled structure, the morphology of which (in terms of pore diameter, surface area, and thickness of matter accumulated between adjacent microchannels) can be finely tailored by the averaged molecular weight of PVA, the PVA concentration in the solution, and the freezing rate of the PVA solution. The resulting PVA scaffolds are suitable substrates for drug-delivery purposes, the drug release being controlled (from tens of minutes up to several days) by the morphology of the microchanneled structure. In vitro experiments reveal the efficiency of PVA scaffolds for controlling the release of ciprofloxacin into a bacteria culture medium.