INQUIMAE   12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
Coupling of tyrosine deprotonation and axial ligand exchange in nitrocytochrome c
Autor/es:
DAIANA CAPDEVILA; DAMIAN ALVAREZ-PAGGI; MARIA ANA CASTRO; VERÓNICA TÓRTORA; VERONICA DEMICHELI; DARÍO A. ESTRÍN; RAFAEL RADI; DANIEL H. MURGIDA
Revista:
CHEMICAL COMMUNICATIONS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2014 vol. 50 p. 2592 - 2592
ISSN:
1359-7345
Resumen:
Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.