INQUIMAE   12526
INSTITUTO DE QUIMICA, FISICA DE LOS MATERIALES, MEDIOAMBIENTE Y ENERGIA
Unidad Ejecutora - UE
artículos
Título:
Tetrachlorocarbonyliridates: Water-Soluble Carbon Monoxide Releasing Molecules Rate-Modulated by the Sixth Ligand
Autor/es:
DAMIAN E. BIKIEL; ESTEFANA GONZLEZ SOLVEYRA; FLORENCIA DI SALVO; HUMBERTO M. S. MILAGRE; MARCOS N. EBERLIN; RODRIGO S. CORREA; JAVIER ELLENA; DAR√ćO A. ESTRIN; FABIO DOCTOROVICH
Revista:
INORGANIC CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2011 vol. 50 p. 2334 - 2334
ISSN:
0020-1669
Resumen:
A new family of compounds is presented as potential carbon monoxide releasing molecules (CORMs). These compounds, based on tetrachlorocarbonyliridate(III) derivatives, were synthesized and fully characterized by X-ray diffraction, electrospray mass spectrometry, IR, NMR, and density functional theory calculations. The rate of CO release was studied via the myoglobin assay. The results showed that the rate depends on the nature of the sixth ligand, trans to CO, and that a significant modulation on the release rate can be produced by changing the ligand. The reported compounds are soluble in aqueous media, and the rates of CO release are comparable with those for known CORMs, releasing CO at a rate of 0.03-0.58 μM min-1 in a 10 μM solution of myoglobin and 10 μM of the complexes.