TREATMENT OF IRRADIATED MICE WITH ORAL RADIOPROTECTOR ATTENUATES INSULT.

MONDRAGON L.; CANTERO F.; CERVANTES L.; FAVANT J.; MARTINEZ MARIGNAC V.; OERTLIN G.

Mar del Plata

Otro; Reunión Anual de SOCIEDADES DE BIOCIENCIA; 2019

SAIC . SAFE . SAB . SAP AACYTAL . NANOMED-ar . HCS

Ionizing radiation directly affects DNA structure by inducing primarily DNA double strand breaks (DSBs), and secondarily production of reactive oxygen species (ROS) that oxidize proteins, lipids, and also induce several different damages to DNA, like generation of abasic sites and single strand breaks (SSB). Consequently, all these changes induce cell death and mitotic failure. The important use of IR in X ray exams and in radiotherapy and its undesirable effects took us to validate a murine model in order to evaluate DNA damage of X Rays and characterize natural and food supplements compounds with radio mitigation properties. Essiac Genuine tea has been used widely in the homeopathy market as a popular anticancer and antioxidant tonic. Due to the reported ROS scavenging properties of Essiac formula, we evaluate DNA damaged mitigation in 50 male Balb/c mice under 25-100mSv-Gy, which is an average effective dose received by most X Ray exams during a year of radioimaging services by its personnel. The tea formula resulted in a significant reduction of DNA damaged of mice under the formula evidenced by Comet Assay (p-Value