INFINA (EX INFIP)   05545
INSTITUTO DE FISICA INTERDISCIPLINARIA Y APLICADA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effects of pulse addition in electropermeabilization: implications on the electric conductivity
Autor/es:
C SUÁREZ; N OLAIZ; F MAGLIETTI; A SOBA; G MARSHALL
Lugar:
Portoroz
Reunión:
Congreso; 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies; 2016
Resumen:
The electrochemical treatment (ECT) is anelectropermeabilization (EP) technique widely studied atpresent due to its numerous applications, as the treatment ofsolid tumors, among others. The applied voltage, as well astissue electric conductivity, are of utmost importance forassessing final electropermeabilized area following an ECT.Experimental results from literature report that a succession ofpulses may increase tissue electric conductivity and the amountof tissue permeabilization. We present here new theoreticalimplications of a novel mathematical model that takes intoaccount the effect of pulse addition in the application of ECTprotocols through the introduction of a new formulation of theelectric conductivity. The model describes the electric fielddistribution by a nonlinear Laplace equation with a variableconductivity coefficient depending on the electric field, thetemperature and the amount of pulses, and the Penne?sBioheat equation for temperature variations. We present heretheoretical predictions about the electric potential, electricfield, electric current, electric conductivity and temperaturedistributions after a given ECT protocol derived from animplementation of the model in the Fortran code as well asfrom the Comsol package. Both implementations describecorrectly the rise in the electric current density observedexperimentally during the addition of pulses, rise that may beexplained by an increment in the tissue electric conductivity,with no significant changes in the electric field. The ECTmodel introduced here, based on a novel formulation of theelectric conductivity, leads to a more realistic description of theEP phenomenon, hopefully providing more accuratepredictions of treatment outcomes.