INFINA (EX INFIP)   05545
INSTITUTO DE FISICA INTERDISCIPLINARIA Y APLICADA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
?Effects of pulse addition in electropermeabilization: Theoretical insights on the electric conductivity?;
Autor/es:
C. SUAREZ; A. SOBA; F. MAGLIETTI; N. OLAIZ; G. MARSHALL
Lugar:
Portoroz
Reunión:
Congreso; 1st. World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies; 2015
Institución organizadora:
University of Ljubljana and EU COST Action TD1104
Resumen:
The electrochemical treatment (ECT) of solidtumors is an electropermeabilization technique firmly establishedand widely used. In ECT protocols, pulse intensity aswell as tissue electric conductivity are of utmost importancefor assessing the final electropermeabilized area. Present ECTmathematical modeling based on the solution of the nonlinearLaplace equation for the electric field with a conductivity coefficientdepending on the electric field and the temperaturehave greatly contributed to ECT protocol optimization. However,experimental results from literature report that a successionof pulses may increase tissue electric conductivity and theextent of tissue permeabilization, a phenomenon that presentmodels fail to describe. Here we present new insights of a recentlyintroduced ECT theoretical model that takes into accountthe effect of pulse addition on tissue electric conductivity.The model describes the electric field with the nonlinearLaplace equation with a conductivity coefficient depending onthe electric field, the temperature and the quantity of pulsesapplied. ECT theoretical predictions show that the rise in theelectric current density during the addition of pulses is duesolely to an increment in the tissue electric conductivity withno significant changes in the electric field. A potential consequenceof these results is that, under certain conditions, itwould be possible to obtain larger electropermeabilized areaswith the same pulse amplitude simply by increasing the numberof pulses. The theoretical implications of this new modellead to a more realistic description of the EP phenomenon,hopefully providing more accurate predictions of ECT treatmentoutcomes.*