CONICET | Buscador de Institutos y Recursos Humanos

Advances in the genetic tools available across a wide range of species have made transgenic modeling more versatile than ever before. Transgenic systems are widely used to study the cellular and molecular basis of Alzheimer`s disease (AD). While the trans genic mouse remains the most widely used model system in AD, significant efforts have been made in a variety of other species including nematodes, arthropods, fishes, rats, as well as non human primates. These transgenic systems have enormous value for understanding the pathophysiological basis of AD and have, in some cases, been instrumental in the development of new thera peutic approaches. In this presentation, we`ll discuss the effect of aging in transgenic models of AD as an influencing factor in the phenotypic expression of a neurodegenerative process, the pros and cons of the application of the invertebrates or vertebrates models as tools for developing insight into the biological basis of the disease, the central roles of transgenic models in preclinical testing of new drugs and the outcome of these drugs in the reversion of the clinical symptoms in affected individuals