PALMITOYLETHANOLAMIDE ATTENUATES COCAINE-INDUCED BEHAVIORAL SENSITIZATION AND CONDITIONED PLACE PREFERENCE IN MICE

LADRÓN DE GUEVARA-MIRANDA, DAVID; RODRÍGUEZ DE FONSECA, FERNANDO; ZAMBRANA-INFANTES, EMMA; GALEANO, PABLO; BLANCO, EDUARDO; ROSELL DEL VALLE, CRISTINA; CASTILLA-ORTEGA, ESTELA; SANTÍN, LUIS JAVIER

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2018 vol. 166 p. 1 - 12

0091-3057

Cocaine addiction is a chronically relapsingdisorder characterized by compulsive drug seeking and drug-taking behaviors.Previous studies have demonstrated that cocaine, as well as other drugs of abuse,alters the levels of lipid-based signaling molecules, such as N-acylethanolamines(NAEs). Moreover, brain levels of NAEs have shown sensitivity to cocaineself-administration and extinction training in rodents. Given this background,the aim of this study was to investigate the effects of repeated or acuteadministration of palmitoylethanolamide (PEA), an endogenous NAE, onpsychomotor sensitization and cocaine-induced contextual conditioning. To thisend, the potential ability of repeated PEA administration (1 or 10 mg/kg, i.p.)to modulate the acquisition of cocaine-induced behavioral sensitization (BS)and conditioned place preference (CPP) was assessed in male C57BL/6J mice. Inaddition, the expression of cocaine-induced BS and CPP following acute PEAadministration were also studied. Results showed that repeated administrationof both doses of PEA were able to block the acquisition of cocaine-induced BS. Furthermore,acute administration of both doses of PEA was able to abolish the expression ofBS, while the highest dose also abolished the expression of cocaine-induced CPP.Taken together, these results indicate that exogenous administration of PEA attenuatedpsychomotor sensitization, while the effect of PEA in cocaine-induced CPP dependedon whether PEA was administered repeatedly or acutely. These findings could be relevantto understand the role that NAEs play in processes underlying the development andmaintenance of cocaine addiction.