V3 Spinal Neurons Establish a Robust and Balanced Locomotor Rhythm during Walking

ZHANG, Y.; NARAJAN, S.; GEIMAN, E; GUILLERMO MARCOS LANUZA; VELASQUEZ, T.; SHANKS, B.; AKAY, T.; DYCK, J.; PEARSON, K.; GOSGNACH, S.; FAN, C-M; GOULDING, M.

NEURON

Año: 2008 p. 84 - 96

0896-6273

A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a robust and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord.