The C-Terminal Extension of Chloroplast 2-Cys Peroxiredoxin Is Critical for Interaction with ATP.

FERRERO, D., ARAN, M., RIMMAUDO, L. AND WOLOSIUK, R.A.

BIOCHEMISTRY

AMER CHEMICAL SOC

Lugar: Washington; Año: 2012 vol. 51 p. 2169 - 2171

0006-2960

2-Cys peroxiredoxins (2-Cys Prxs) are ubiquitous enzymes that have been implicated in peroxide-mediated signaling of markedly different processes, such as cancer and photosynthesis. A highlyconserved C-terminal extension of eukaryotic homologues modulates both the overoxidation of cysteines and the formation of oligomers. Here, we reveal that the plant counterpart regulates the self-polymerization of 2-Cys Prx triggered by ATP and Mg2+. This feature is of particular importance under oxidative stress because the interaction of ATP with 2-Cys Prx rapidly integrates nonredox chemistry of signaling pathways into a network hub governed by multiple redox transformations at cysteine residues.