IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Vitamin D serum levels comparison between a cohort of Myasthenia Gravis patients and healthy subjects in Argentina
Autor/es:
AGUIRRE, F; GONZALEZ MAGLIO, DH; JUSTO, ME; LEONI, J; CELA, EM; PAZ, ML
Lugar:
Mar del Plata
Reunión:
Congreso; LXVI Reunión Anual de la Sociedad Argentina de Inmunología; 2018
Resumen:
Myasthenia Gravis (MG) is an autoimmune disease mediated generally by anti-acetylcholine receptor autoantibodies (ACRA), whose production is T cell dependent. Regulation of autoreactive T cells depends on regulatory T lymphocytes (Treg), which are diminished in MG patients. Vitamin D (VitD) has immunomodulatory effects, stimulating Treg and inhibiting effector T cells. As VitD synthesis depends on sunlight exposure, therefore on the country latitude, a controversial association between VitD deficiency and MG development and severity has been established.We aimed to compare 25-OH-VitD serum levels in 61 diagnosed MG patients (19 during MG exacerbation) and 30 healthy volunteers (hv), and to relate them with the severity of the disease (ADL and MGCscales)and other biomarkers in an Argentinian cohort. We collected samples equally distributed through the year. We measured: 25-OH-VitD (chemiluminescence), C3 and C4 (RID), C5a (ELISA), ACRA (RIA).There were no statistically significant (ss) differences in 25-OH-VitD mean serum levels between patients and hv, neither between basal and exacerbated patients. When we analyzed 25-OH-VitD mean serum levels of subjects grouped according to the season of sampling, we found a ss difference in spring (p=0,043) between patients (13,42 ng/ml) and hv (18,11 ng/ml). Deficient levels of 25-OH-VitD (