IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
DUAL EFFECTS OF SAGS OF THE EGC OPERON ON INNATE IMMUNE CELLS
Autor/es:
SARRATEA, BELÉN; EMILIO L. MALCHIODI; NOLI TRUANT, SOFIA; IANNANTUONO LÓPEZ, LAURA; FERNÁNDEZ MARISA MARIEL; ANTONOGLOU, BELÉN; JANCIC, CAROLINA
Lugar:
Cancún
Reunión:
Congreso; XII Congress of the Latin American Association of Immunology (ALAI); XXIII Congress of the Mexican Society of Immunology (SMI).; 2018
Institución organizadora:
Latin American Association of Immunology (ALAI)
Resumen:
Bacterial superantigens (SAgs) are enterotoxins that bind to MHC-II and TCR molecules, activating as much as 20% of T cells and promoting a cytokine storm which enhances endotoxic shock and produces immunosuppression, hindering the immune response against bacterial infection. The egc operon reported in Argentinian autochthonous S. aureus strains includes natural variants of SAgs genes seg, sei, sem, sen and seo, each of one appears to present complementary activity upon the immune system.In the present work, we investigated the effect of SEG, SEI, SEO and SEM on different cells of the innate immune response. At first, we examined the effect of SAgs on monocytic Thp-1 cells. We observed a wide capacity of the four SAgs to inhibit their proliferation by thymidine: at the maximum concentrations SEO, SEG and SEI inhibited up to 70% and SEM inhibited near 30% (p