Different RHAMM expression pattern in Gestational Trophoblastic Disease (GTD)?.

MASCARÓ M.; ZOTTA E; BIANCONI MI; LAGO N; LOMPARDÍA S. L.; OTERO S.; E ALVAREZ; JANKILEVICH G; SILVIA HAJOS

Foz de Iguazu

Simposio; V SLIMP (Latin American Symposium on Maternal Fetal Interaction & Placenta) and IV LASRI (Latin American Symposium on Reproductive Immunology); 2013

GTD constitutes a group of disorders that arises from the placental trophoblast. It includes hydatiform mole (HM) and malignant tumors like choriocarcinoma (CC) and placental-site-trophoblastic tumor (PSTT). They represent malignant fetal allografts in maternal tissues. Hyaluronan is a prominent component of tumoral microenvironment involved in tumor survival and progression by interaction with its receptors, CD44 and RHAMM. We analyzed the presence and distribution of such molecules in GTD by immunohistochemistry. Tissues from 10 HM, 2 CC and 1 PSTT were collected from the Pathology Service approved by the Ethics Committee of Hospital ?Carlos Durand?, Buenos Aires, Argentina. We found different subcellular distribution of RHAMM in GTD tissues while hyaluronan and CD44 are related to the stroma in choriocarcinoma suggesting that these molecules are involved in the pathogenesis of GTD. Additional work is necessary to elucidate their involvement in migration, invasion and metastasis processes as well as in immune response modulation.