IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Systemic inflammatory response and oxidative stress following an acute exposure to environmental particulate matter
Autor/es:
MARCHINI T; MAGNANI ND; PAZ ML; TASAT D; GONZÁLEZ MAGLIO DH; ALVAREZ S; EVELSON PA
Reunión:
Congreso; VIII Meeting of the Society for Free Radical Biology and Medicine ? South American Group; 2013
Resumen:
The
exposure to environmental particulate matter (PM) is associated with increased morbidity
and mortality ratesdue to cardiopulmonary diseases.In this context, a systemicinflammatory
response and oxidative stressare suggested to play a predominant role. The aim
of this work was to evaluate this hypothesis, in an in vivoanimal model of acute exposure to PM. Mice were intranasally
instilled with Residual Oil Fly Ashes (ROFA) (1 mg/kg). Plasmatic cytokine
profile, TBARS and carbonyl content, GSH and GSSG levels, ascorbic acid content,and
SOD activity were evaluated 3 h after the exposure. TBARS and carbonyl content
were significantly increased by 19% and 12%, respectively, in comparison with
the control group.In ROFA-exposed mice, GSH was decreased
by 27% while GSSG was increased by 42%, leading to a 50 % decrease in GSH/GSSG
ratio (control 10.6). Ascorbic acid content and SOD activity were significantly
decreased by 29% and 38%, respectively, in ROFA-exposed mice.This scenario was
accompanied by asignificant increase inplasmatic levels of proinflammatorycytokines
(TNF-α and IL-6)after the ROFA exposure. The present findings may provide new
evidence on the mechanism by which an acute exposure to environmental PM leads
to adverse health effects.