RHAMM expression pattern in Gestational Trophoblastic Disease (GTD)

MASCARÓ M, ZOTTA E, BIANCONI MI, LAGO N, LOMPARDÍA S, OTERO S, ALVAREZ E, JANKILEVICH G, HAJOS SE.

San Pablo

Congreso; Presentado en V SLIMP Latinamerican Symposium on Maternal Fetal Interaction & Placenta; 2013

SLIMP

RHAMM expression pattern in Gestational Trophoblastic Disease (GTD)   Mascaró, M; Zotta, E; Bianconi, MI; Lago, N; Lompardía, S; Otero S; Alvarez, E; Jankilevich, G; Hajos, SE.   GTD constitutes a group of disorders that arises from the placental trophoblast. It includes hydatiform mole (HM) and malignant tumors like choriocarcinoma (CC) and placental-site-trophoblastic-tumour (PSTT). They represent malignant fetal allografts in maternal tissues. Hyaluronan is a prominent component of tumoural microenvironment involved in tumour survival and progression by interaction with its receptors, CD44 and RHAMM. We analyzed the presence and distribution of such molecules in GTD by immunohistochemistry. Tissues from 10 HM, 2 CC and 1 PSTT were collected from the Pathology Service approved by the Ethics Committee of Hospital “Carlos G Durand”, Buenos Aires, Argentina. We found different subcellular distribution of RHAMM in GTD tissues while hyaluronan and CD44 are related to the stroma in choriocarcinoma suggesting that these molecules are involved in the pathogenesis of GTD. Additional work is necessary to elucidate their involvement in migration, invasion and metastasis processes as well as in immune response modulation.   Key Words: Gestational-trophoblastic-disease, hyaluronan, CD44, RHAMM