IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A BRUCELLA PROTEASE INHIBITOR IS A USEFULL ADJUVANT IN ORAL VACCINE FORMULATIONS.
Autor/es:
GABRIELA SOFIA RISSO; ANDRÉS E. IBAÑEZ; M. LORENA CORIA; KARINA A. PASQUEVICH; M. VICTORIA DELPINO; C. GABRIEL BRIONES; JULIANA CASSATARO
Lugar:
Campos do Jordao
Reunión:
Congreso; XXXVII Congress of the Brazilian Society of Immunology; 2012
Institución organizadora:
Sociedad Brasilera de Inmunología
Resumen:
Introduction: Previous results showed that a Brucella protein (BP) administered by the oral route and without adjuvants induced protection against oral Brucella challenge. These results indicated that BP had self-adjuvant properties and prompted us to study its potential application as adjuvant for other antigens (Ags). Methods and Results: Our results indicated that BP is a broad spectrum protease inhibitor with a stronger activity against serine proteases secreted by the pancreas to the intestine (elastase, trypsine and alpha chymotrypsin; p