IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
artículos
Título:
Ovarian Stimulation Affects the Levels of Regulatory Endometrial NK Cells and Angiogenic Cytokine VEGF.
Autor/es:
JUNOVICH G; MEYER I; ASPIROZ A; GENTILE T; PASQUALINI S.; MARKERT U; GUTIERREZ G
Revista:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Oxford; Año: 2010
ISSN:
1046-7408
Resumen:
Problem Endometrial NK cells play a critical role in uterine
vascularization producing angiogenic factors. Impact of ovarian
stimulation on endometrial expression of NK cells and VEGF in normal
fertile oocyte donors and the effect of endometrial injury treatment on
these parameters have been investigated. Method of study Endometrial
tissue was obtained from oocyte donors during natural and stimulated
cycles. NK cell subsets were measured by flow cytometry. VEGF was
determined by ELISA and flow cytometry. Endometrial angiogenic
parameters were determined by ultrasound Doppler. Local injury was
induced by scratching endometrial tissue previous to implantation
window. Results Ovarian stimulation decreased endometrial levels of NK
cells and vascularization index but increased VEGF levels. Local injury
normalized only the CD56(+) NK cell count. Conclusion Hormonal therapy
for ovarian stimulation may be associated with poor endometrial
vascularization. Local injury before the implantation window seems not
to influence endometrial angiogenic parameters altered by ovarian
stimulation.