Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice.

JUNOVICH G; DUBINSKY V; GENTILE T; SARTO ADRIANA; PASQUALINI S.; GUTIERREZ G

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Oxford; Año: 2010

1046-7408

Citation Junovich G, Dubinsky V, Gentile T, Sarto A, Pasqualini S, Gutiérrez G. Comparative immunological effect of anticoagulant and antioxidant therapy in the prevention of abortion in mice. Am J Reprod Immunol 2010 Problem Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. Method of study Pregnant females from CBA/J x DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. Results Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. Conclusion Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias.