Treatment with <i>Enterococcus faecalis</i> CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status

DÍAZ, AILÉN M.; MOURELLE, ANA C.; CASTRO, MARISA S.; NUÑEZ, GUILLERMO G.; MANGHI, MARCELA A.; NUÑEZ, GUILLERMO G.; MANGHI, MARCELA A.; MOLINA, MATÍAS A.; SPARO, MÓNICA D.; MOLINA, MATÍAS A.; SPARO, MÓNICA D.; DÍAZ, AILÉN M.; MOURELLE, ANA C.; CASTRO, MARISA S.

Advances in Microbiology

Scientific Research Publishing

Lugar: Wuhan; Año: 2017 vol. 07 p. 696 - 706

2165-3402

In allergies, an unbalanced immune response towards a T helper (Th) 2 profilewith high levels of Immunoglobulin (Ig) E is produced. We have demonstratedthat the pre-administration of Enterococcus faecalis CECT7121 preventsthe development of allergy in ovalbumin-immunized mice. In this work,we evaluated whether this bacterium can also revert an established allergicstatus. Mice were immunized with ovalbumin (OVA) and after that, were inoculatedwith an E. faecalis CECT7121 suspension. In immunized animals,serum specific immune response, proliferative activity of memory splenocytes,and levels of Th2 cytokines were assessed. The in vivo active cutaneous anaphylaxis test was also performed. The treatment with E. faecalis CECT7121only increased anti-OVA IgG2a levels. No differences were observed in otherspecific immunological parameters. Probiotic-treatment did not prove to haveany desensitizing effect on mice. These results, together with those recentlypublished, can be concluded that this bacterium would not be appropriate forthe treatment of allergic symptoms.