IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
artículos
Título:
Expression of HLA-G and MICA mRNA in renal allograft
Autor/es:
A RACCA, C VEAUTE,A BAILAT, L GAITE, M ARRIOLA, S HAJOS, I MALAN BOREL
Revista:
TRANSPLANT IMMUNOLOGY
Editorial:
Elsevir
Referencias:
Lugar: USA ; Año: 2009 vol. 21 p. 10 - 12
ISSN:
0966-3274
Resumen:
Abstract: HLA-G is a nonclassical MHC class I antigen that displays tolerogenic functions; MICA is
a stress-regulated molecule recognized by NKG2D cytotoxicity-activating receptor expressed by
NK and T cells subsets. We evaluated HLA-G isoforms and MICA mRNA levels in peripheral blood
mononuclear cells (PBMCs) and in biopsies from kidney allograft recipients with acute rejection
(AR), chronic rejection (CR), and stable graft evolution (SE). HLA-G1 was the only transcript
resulted from amplification, both in PBMCs as in biopsy samples. HLA-G1 mRNA levels in PBMCs
from 9/10 patients with CR, 7/9 with AR and 8/10 healthy volunteers were below the median value
of SE patients. The analysis of biopsies revealed that patients with AR (n=6), who overcame
rejection had a tendency towards higher HLA-G1 levels than those with nephrotoxic acute tubular
necrosis (ATN) (n=3). Similar levels of MICA expression were observed in PBMCs from AR, CR,
SE and C groups; MICA expression levels were similar also in biopsy specimens from AR and
nephrotoxic ATN patients. No correlation was found between MICA expression and the graft state.
These results suggest that HLA-G1 isoforms, but not MICA mRNA levels, may provide a marker for
measuring the state of kidney allograft and perhaps its evolution.
nephrotoxic ATN patients. No correlation was found between MICA expression and the graft state.
These results suggest that HLA-G1 isoforms, but not MICA mRNA levels, may provide a marker for
measuring the state of kidney allograft and perhaps its evolution.
nephrotoxic ATN patients. No correlation was found between MICA expression and the graft state.
These results suggest that HLA-G1 isoforms, but not MICA mRNA levels, may provide a marker for
measuring the state of kidney allograft and perhaps its evolution.
nephrotoxic ATN patients. No correlation was found between MICA expression and the graft state.
These results suggest that HLA-G1 isoforms, but not MICA mRNA levels, may provide a marker for
measuring the state of kidney allograft and perhaps its evolution.