IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
artículos
Título:
Frequency of markers of autoimmunity to islet beta cell in patients with autoimmune thyroid disease
Autor/es:
M.E. PRIMO, H. NIEPOMNISZCZE, E. POSKUS, M.S. SALA, S.S. GUAITA, M.P. SICA, A. VILLALBA, A. CARDOSO, O.D. BRUNO
Revista:
Medicina (buenos Aires)
Editorial:
Fundación Revista Medicina
Referencias:
Lugar: Buenos Aires; Año: 2007
Resumen:
A total of 305 ambulatory patients recruited at the Division of Endocrinology, Hospital de Clínicas,
University of Buenos Aires, with autoimmune thyroid disease (AITD) were studied to search for
associations between autoimmune thyroid disease and presence of serum markers of autoimmune diabetes
mellitus. Screening for markers of pancreatic beta-cell autoimmunity was performed by radioligand binding assays
(RBA) as follows: autoantibodies to glutamic acid decarboxylase (GADA) and proinsulin (PAA) were determined
in all sera, whereas autoantibodies to protein tyrosine phosphatase (IA-2A) and insulin (IAA) were additionally
measured in 200 sera randomly selected from the total collection. In addition, every GADA positive serum among
the remaining 105 sera was systematically tested for the presence of IA-2A and IAA. In the cohort of 305 AITD
patients 22 (7.2%) were previously diagnosed as type 1, type 2 or insulin-requiring type 2 diabetics. Ten of these
patients presented serum marker positivity specific for b-cell autoantigens and 12 were marker negative. On the
other hand, considering the majority of non-diabetic AITD patients (283), b-cell marker positivity was detected in
17 individuals (6.0%). The prevalence of autoimmune diabetes markers was much higher in the studied population
than in the general population utilized as a control group, and GADA was the most frequent marker.