IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
artículos
Título:
Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against ultraviolet-induced carcinogenesis.
Autor/es:
WEILL FS; CELA EM; PAZ ML; FERRARI A; LEONI J; GONZÁLEZ MAGLIO DH
Revista:
BRITISH JOURNAL OF NUTRITION
Editorial:
CAMBRIDGE UNIV PRESS
Referencias:
Lugar: Cambridge; Año: 2012 p. 1 - 1
ISSN:
0007-1145
Resumen:
Probiotics are defined as “live microorganisms that when administered in adequate amounts confer a health benefit on the host”. Cell surface molecules and extracellular components of these microorganisms are being studied in relation to their ability to interact with the host. The cell wall of lactobacilli comprises lipoteichoic acids (LTA) which are macroamphiphilic molecules with immunomodulatory properties. Ultraviolet radiation (UVR) has been proposed as the main cause of skin cancer because of its mutagenic and immunosuppressive effects. Recently, the prevention of the harmful effects of UVR has been demonstrated for some probiotics. The aim of our study was to investigate whether the oral administration of purified LTA from Lactobacillus rhamnosus GG can modulate the immune suppressive effect of UVR and skin tumor development in female Crl:SKH-1-hrBR hairless mice. Two irradiation models were studied: 1. a chronic irradiation scheme consisting of daily irradiations during 20 consecutive days, and 2. a long-term irradiation schedule, irradiating the animals 3 times a week, during 34 weeks for tumor development. We found that T cells in the inguinal lymph node of LTA treated mice produced significantly higher levels of 1. IFN-g, and 2. number of total, helper and cytotoxic T cells versus non-treated mice. Moreover, a significant delay in tumor appearance was found in mouse treated with LTA. The finding of increased IgA+ cell number in small intestine and higher number of activated dendritic cells in mesenteric lymph nodes may indicate a direct effect of LTA in the gut, which could affect cutaneous immune system and restore homeostasis through the gut-skin axis.