IDEHU   05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
artículos
Título:
Is the Polycystic Ovary Syndrome the causative of the increase in inflammatory markers and metabolic risk?
Autor/es:
ESTELA BEATRIZ REY; PEREZ LANA MB , GALLUZZO L , BLANCO G , ONETTO C , STRAMINSKY V , NOLTING M .
Revista:
GYNECOLOGICAL ENDOCRINOLOGY
Editorial:
INFORMA HEALTHCARE
Referencias:
Lugar: London; Año: 2012 vol. 29 p. 141 - 144
ISSN:
0951-3590
Resumen:
Aims: To investigate the relationship between the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and IL-1ß and the hormonal and metabolic alterations in women with polycystic ovary sindrome (PCO). Materials and Methods: Case-control study. CRP, IL-6 and IL-1beta were evaluated in combination with obesity, insulin resistance (IR) and hyperandrogenism parameters in 20 patients with PCO. Twenty healthy women were used as the control. Results: The average CRP values was 5.1 in the cases vs 0.8 mg/l in control group (P<0.0001). The IL-6 average values were 2.77 in the cases vs 2.70 pg/ml in the control group (p=0.254). IL-1beta levels were found to be within the normal range in all individuals. A positive correlation was found between the CRP values and the IR (P <0.0001) as well as with the presence of obesity (P<0.02). No correlation was found between PCR and hyperandrogenemia (p=0.4) nor between IL-6 values and IR (P =0.3), or between the levels of this cytokine and the presence of hyperandrogenemia (P=0.2). A significant correlation was found between IL-6 levels and obesity (P< 0.0001). Conclusions: The present study demonstrates the presence of a chronic inflammation status in young women with PCO. These parameters are mainly related to obesity and, to a lesser extent, to insulin resistance.