IDEHU 05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
artículos
Título:
Protein deficiency during Trichinella spiralis infection impairs lung immunity against newborn larvae
Autor/es:
VILA, CECILIA C.; FALDUTO, GUIDO H.; PALLARO, ANABEL N.; SARACINO, MARÍA P.; DÍAZ, MARIÁNGELES; BALDI, PABLO C.; LOMBARDO, TOMÁS; CALCAGNO, MARCELA A.
Revista:
PARASITE IMMUNOLOGY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2021 vol. 43
ISSN:
0141-9838
Resumen:
The goal of this study was to analyse the effects of a protein-deficient (PD) diet on antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro against newborn larvae (NBL) of Trichinella spiralis in the lungs of infected rats. Two groups of weaning Wistar rats received a PD diet (6.5% casein) and other two received a control diet (C, 20% casein). After ten days, one group of each diet was infected (PDI and CI) with muscle larvae. Lung tissue extracts (LTE) and lung cell suspension (LCS) were obtained. PDI had lower titres of anti-NBL antibodies in LTE than CI. In ADCC assays using control cells, NBL mortality percentage was lower with LTE from PDI than LTE from CI (P
