IDEHU 05542
INSTITUTO DE ESTUDIOS DE LA INMUNIDAD HUMORAL PROF. RICARDO A. MARGNI
Unidad Ejecutora - UE
artículos
Título:
Hyaluronan induces migration of multidrug resistant lymphoma cell lines in vitro through Tiam1 activation by a PI3K-dependent mechanism.
Autor/es:
CORDO RUSSO RI; ALANIZ LD; SACCODOSSI N; LOMPARDÍA S; BLANCO G; ALVAREZ E; GARCÍA MG; HAJOS SE
Revista:
LEUKEMIA RESEARCH
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2010 vol. 34 p. 1525 - 1532
ISSN:
0145-2126
Resumen:
Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacity towards HA in vitro as well as higher constitutive active Tiam1 expression than the sensitive cell line. Besides, HA treatment induced migration towards HA of MDR cell lines through Tiam1 activation by a PI3K-dependent mechanism, showing that disruption of HA signaling would be useful in treatment of MDR hematological malignancies.
