Sesquiterpene lactones. Advances in their Chemistry and Biological Aspects

SPINA R; SCOTTI L; MARTINO R; LOMBARDO E; DONADEL O; DA COSTA F; CATALAN C; VÍCTOR DANIEL BUSTO; ALCIRA BATLLE; ANESINI C; SANCHEZ ALBERTI A; TONN C; SOSA M; SCHMIDT T; LOZANO E; RODRIGUEZ TALOU J; ANA MARÍA GIULIETTI; MARCUS TULLIUS SCOTTI; FLAVIA FERNANDES DA SILVEIRA; PERASSOLO M; CERNY N; NOELI LOPEZ S; CASTELLI V; GIBERTI G; BOECHAT N; LUIZ CARLOS DA SILVA PINHEIRO; BARRIOS F; CAZORLA S; MATEUS FEITOSA ALVES; ALEJANDRA B CARDILLO; MARTINO V; BIVONA A; BARRERA P; ALONSO MR; SÜLSEN V

Springer International Publishing AG

Año: 2018 p. 371

978-3-319-78273-7

Although some interesting reviews on sesquiterpene lactones have been published,many advances have recently been made in this field, which implies the necessity of an update.The aim of this book is to review such recent advances made in the study of sesquiterpene lactones, discussing their potential medical applications.Different aspects will be reviewed, such as the distribution and taxonomy; thebiosynthetic pathways; their chemistry, including the synthesis and chemical andbiological transformations as well as the analytical isolation and identification procedures most frequently employed. Their biological properties mainly focused on the antimicrobial, antiproliferative, and anti-inflammatory activities and structure activity studies will be also summarized. An update on the main molecular targets for their antiprotozoal activity will also be presented.It is expected that this book will serve as a source of information to scientific researchers and postgraduate students, being inspiring for the performance of further studies on the chemistry and the biological activities of this fascinating group of compounds. Finally, the aim of this book is to highlight the importance of sesquiterpene lactones as lead molecules for the development of new therapeutic drugs.