IQUIMEFA 05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effect of cumanin diacetate, a sesquiterpene lactone derivative, on an in vivo chronic model of chagas disease.
Autor/es:
SANCHEZ ALVERTI A; MALCHIODI E; BEER, MARÍA F.; CERNY N; VALERIA PATRICIA SULSEN; BIVONA A; DONADEL, OSVALDO J.
Lugar:
CABA
Reunión:
Congreso; Discovery for Neglected Diseases International Congress 2018 (ResNet NPND); 2018
Resumen:
Chagas´ disease is a parasitic disease caused by the protozoan parasite Trypanosoma cruzi. It is considered, among others, a NeglectedTropical Disease. The drugs currently in use for the treatment of this parasitosis are not effective in chronic stages and have severe drawbacks.Sesquiterpene lactones (STLs) are a group of natural terpenoids with a wide range of biological activities, being antiparasitic and antitumoramong the most relevant.Chemical modification of natural compounds is a strategy to enhance the activity and reduce toxic effects.
