PRENATAL AND POSTNATAL ZINC DEFICIENCY EXACERBATES THE CARDIOVASCULAR EFFECTS OF ANGIOTENSIN II

MENDES GARRIDO ABREGÚ, FACUNDO; SORIA DAMIÁN; TOBLLI JORGE; TOMAT ANALÍA; GOBETTO NATALIA; BANDIERA SOFÍA; CASTAÑÓN AGUSTINA; CANIFFI CAROLINA; CIANCIO NICOLÁS; SARAVIA MELISA; ECHEVERRÍA PAREDES FRANKLIN; ELESGARAY ROSANA; ARRANZ CRISTINA

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de BioCiencias; 2017

Comité Organizador Reunión Conjunta de Sociedades de BioCiencias

Zinc deficiency (ZD) programs cardiovascular alterations in male rats. Objective: To evaluate the cardiovascular effects of chronic infusion with angiotensin II (AII) in male rats subjected to prenatal and postnatal ZD.Method:Wistar rats fed during pregnancy until weaning control (C,30ppm) or zinc deficient (B,8ppm) diets. At weaning, C male offspring continued on C diet (CC) and B offspring received B or C diets for 60 days (BB, BC). At 67 days of life, subcutaneous infusions of AII (65 ng/min/rat) or 0.9% NaCl were administered to animals for 14 days using osmotic pumps (Model 2002,Alzet,Palo Alto,USA). Systolic blood pressure (SBP,tail-cuff method,mmHg); cardiac(C) and aortic(A) inflammatory markers (TNFα,IL-6;IHQ; %area marked/total tissue area); perivascular collagen/lumen area(C/L) and media/lumen area(M/L) of A and C arteries (sirius red staining) were determined at 81 days. ANOVA, Bonferroni post-hoc test (n=6/group,αp