Stevia´s cardioprotective effects

JULIANA PEREGO; M.G MARINA PRENDES; D VELEZ; HERMANN R; MESTRE CORDERO, VICTORIA EVANGELINA; JULIANA PEREGO; M.G MARINA PRENDES; D VELEZ; HERMANN R; MESTRE CORDERO, VICTORIA EVANGELINA

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Stevia rebaudianabertoni, an herbaceous plant widely distributed and used in Paraguay and Brazil for its sweetener character, has several medicinal properties including antimicrobial, antiviral, antifungal, antitumor, antihypertensive, antiinflammatory, hepatoprotective and immunostimulant actions. The aim of the present study was to investigate the cardioprotective effects of oral stevioside (E, 168 mg/kg for 15 days), a major component of stevia, in Langendorff perfused rat hearts subjected to ischemia (I)-reperfusion (RP). Hearts from female Wistar rats (200-250 g) fed ad libitum were used. The contractility was evaluated by determining the left ventricular developed pressure (LVDP), rate-pressure product (RPP) was determined by multiplying heart rate (HR) by LVDP, peak rate of contraction and peak rate of relaxation (± dP / dt), and the left ventricular end-diastolic pressure was measured (LVEDP). The creatine kinase (CK) release was determined in the coronary effluent during the first 10 min of RP and the myocardial infarct size (MIS) was determined by staining with triphenyltetrazolium chloride (TTC) dissolved in phosphate buffer. ANOVA, n = 8 / group. E improved postischemic recovery compared to the control group (C) (RPP (%) at 30 min RP: C 55.5 ± 8.8, E 87.2 ± 14.8 *, * p