CARDIOVASCULAR RISK FACTORS PROGRAMMED BY ZINC DEFICIENCY DURING GROWTH

MENDES-GARRIDO F; SCHÄFER S; SCHREIER L; GOBETTO MN; ARRANZ C; LUCERO, D; CASTAÑÓN A; TOMAT AL; ELESGARAY R

Paris

Congreso; 26th Meeting on Hypertension and Cardiovascular Protection; 2016

European Society of Hypertension

ObjectiveModerate zinc deficiency during intrauterine and postnatal growthinduces an increase in blood pressure levels, vascular remodelling and adecrease in vascular nitric oxide production in adult males.The objective was to evaluate serum metabolic profile and aorticfunction in adult male rats exposed to fetal and postnatal zinc deficiency.Design and methodFemale Wistar rats received during pregnancy up to weaning low (L:8 ppm)or control (C:30 ppm) zinc diet. After weaning, male offspring fed low (l) orcontrol (c) zinc diet (Cc, Ll, Lc).until 81 days of life.At day 81, we measured systolic blood pressure (SBP,mmHg, tailcuff technique),serum fasting glucose and lipid profile. In aortic rings suspended in Krebssolution we evaluated: maximal contraction (Rmax) to phenylephrine (PE, 109-105M),angiotensinII (AngII, 1010-106M) and caffeine (25mM),expressed as % of maximal contraction with KCl 90mM. In aortic ringspreconstricted with PE 105M, we measured the maximal relaxation withacetylcholine (ACh, 1010 -103M) and sodium nitroprusside(SNP, nitric oxide donor, 1011105M).ResultsValues are means±SEM, n=6/group. One way ANOVA, Bonferroni posttest *p