Thiosemicarbazones: Potential antitumor agents against breast cancer

LOAIZA PÉREZ ANDREA; CALLERO MARIANA; SORAIRES SANTACRUZ MARÍA CRISTINA; FINKIELSZTEIN LILIANA; SOLIMO ALDANA; BAL DE KIER JOFFE ELISA

Mar del Plata

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC), LXIV Reunión Anual de la Sociedad Argentina de Inmunología (SAI), XLVIII Reunión Anual de la Sociedad Argentina de Farmacología Experimental (SAFE); 2016

The propose of this work is to nvestigate the anti-tumor effects of three TSCs (T1, T2 y T3) on breast cancer cell lines with differential expression of membrane receptors. The results showed that: T1 and T2 exert an apoptotic cytotoxic effects only on tumorigenic breast cell; TSCs treatment reduce tumor stem cells in MCF-7 and BT 474 cell. BT 474 cells with mammosphere formig capacity were more sensitive to TSCs tan MCF-7 cells; T1 and T2 dimish cell migration capacity on MDA-MB 231 cell line.