In vitro antiviral activity against Bovine Viral Diarrhea Virus (BVDV) and structure-activity relationship of new N4-arylthiosemicarbazones derived from 1-indanones

M. FABBIANI, E. CASTRO, M. SORAIRES SANTACRUZ, L. FINKIELSZTEIN, L. CAVALLARO.

Conferencia; 29th International Conference on Antiviral Research; 2016

In order to find compounds with an improved anti-BVDV activity, new TSCs with other substituents on the aromatic ring of the indanic nucleus and different substitution patterns, as well as N4-substituted TSCs with phenyl groups (N4-TSCs) were synthesized. The 5,6-dimethoxy substitution in the indanic nucleus resulted to be the best for the antiviral activity. Compound 11 was the most active compound of the whole series (EC50=0.7±0.3μM), six-fold higher than the Lead Compound.