EFFECTS OF AUTOPHAGY INHIBITOR, 3-METHYLADENINE, ON ISOLATED ATRIA SUBJECTED TO SIMULATED ISCHEMIA-REPERFUSION

HERMANN, R; MESTRE CORDERO, V; RUSIECKI, T; FERNÁNDEZ PAZOS, MM; VÉLEZ, D; REZNIK, F; SAVINO, EA; MARINA PRENDES, MG; VARELA, A

Congreso; INTERNATIONAL SOCIETY OF CARDIOVASCULAR PHARMACOTHERAPY 20º ANNUAL MEETING; 2015

Autophagy is a cellular catabolic process that occurs constitutively at a low rate in all eukaryoticcells, mainly for house-keeping purposes. Although autophagy is a prominent feature of myocardial ischemia andreperfusion, the functional significance is unclear and controversial. In order to gain a deeper insight into the role ofautophagy in myocardial ischemia-reperfusion, we explored the effects of the pharmacological inhibitor of autophagy 3-methyladenine (3-MA).