IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Interactions of cells with nanomaterials
Autor/es:
MF DESIMONE
Reunión:
Congreso; SETAC Latin America 11th Biennial Meeting; 2015
Resumen:
Oral Presentation. The application of nanomaterials in different fields experienced a great development. The driving forces for these developments are the possibility to design nanomaterials with specific properties. Moreover, it is possible to tune the characteristics of the nanomaterials to meet the requirements of each specific cell and desired application. Herein, we present different strategies developed to contribute to understand the nature of this inherently complicated cell-nanomaterial interactions. The interaction of cells with materials is focused on nanoporous surfaces, nanoparticles and gels. In the first case it was demonstrated that it is possible to engineering surfaces in terms of wetability, chemical composition and porosity to control cell adhesion. Secondly, results further confirm that the interaction of nanoparticles with mammalian cells depends on their size, surface chemistry and dose among many other experimental parameters. The mammalian cells show high sensitivity to surface modification of the particles. Moreover, cytotoxicity towards L929 fibroblasts was mainly observed for bare particles, whereas sulfonate-, amine- and thiol-grafted particles had less detrimental effects. Finally, recent advances in the synthesis of inorganic and hybrid gels for mammalian cell immobilization are presented. Particularly, results focused in the different characteristics of the gel required for adherent and non-adherent cells are discussed.