MICROWAVE-ASSISTED SYNTHESIS OF CHITOSAN-OLIGO(CAPROLACTONE) GRAFT COPOLYMERS FOR DRUG DELIVERY APPLICATIONS

S QUINTANA; RJ GLISONI; AG MOGLIONI; A SOSNIK

Athens

Conferencia; 5to BBBB International Conference; 2013

A series of CS-g-PCL copolymers were synthesized by microwave-assisted technology under very mild temperature conditions. The reaction time was 10 min and the monomer conversion above 90%. The grafting of oligo(CL) blocks was confirmed by FT-IR and NMR. Graft copolymers were readily soluble in DMSO and acetone, as opposed to pristine CS. DSC and TGA analysis showed different degradation mechanisms due to structural difference between the two polymers, while WAXD analysis revealed that the degree of crystallinity of CS in the copolymer was reduced upon graft copolymerization.