Antinociceptive activity of the vanillic acid

YRBAS A; MORUCCI FLORENCIA; ALONSO MARÍA ROSARIO; SUSANA GORCZALZANY

Buenos Aires

Conferencia; VI International Conference on Polyphenols and Health ICPH-6; 2013

Facultad de Farmacia y Bioquímica UBA e Instituto de Bioquímica y Medicina Molecular UBA - Conicet

Vanillic acid is found at high concentrations in many plants used in traditional medicine. It has been associated with a variety of pharmacologic activities such as inhibiting carcinogenesis, apoptosis and inflammation but it has become most popular for its pleasant creamy odour. Since there are few reports method, showed that its T1/2 and ABC were 0.123h and 1.38 µg. h/ml, respectively. In about the antinociceptive activity of this phenolic compound, the aim of this work was to study this activity on in vivo models. Vanillic acid administered by intraperitoneal route (i.p.), produced a dose-related inhibition of acetic acid-induced writhing response (ED50: 18.4 mg/kg). The antinociceptive activity was inhibited for the pretreatment with ondansetron (0.2 mg/kg i.p.) and yohimbine (1 mg/kg i.p.), indicating that serotoninergic and adrenergic system participate in the mechanism underlying the analgesic activity of this compound. In a suitable in vivo model, this phenol has shown interact with ASIC channels (Acid-sensing Ion Channels) at dose of 100 mg/kg i.p. Furthermore, it did not produce any interference on locomotor function or motor coordination. Plasmatic vanillic acid, analysed by HPLC conclusion, our results suggested that the vanillic acid, might represent potential therapeutic options for the treatment of pain.