Tuning cell material interactions for biomedical applications

*MF DESIMONE

Campos do Jordao

Congreso; XII Brazilian Material Research Society Meeting; 2013

Invited lecture: At present, understand the interaction between cells and materials represents an active area of biomaterials research that aims to meet the requirements of each cell? biomaterial interaction. In this sense, cell?biomaterial interactions are largely governed by the stiffness and chemical composition of the substrate, although the surface topography has also been shown to play an important role in the adhesion and proliferation of various cell types to different substrates. Moreover, the great advances in the application of silica nanoparticles also require a careful characterization of the biocompatibility, immune response and toxicological effects that they may cause. The study of the immune response against nanoparticles is actually being studied for multiple reasons such as the elucidation of new targets for drug delivery systems, as vaccination adjuvants or for toxicological studies. In the present work, the interaction of cells with materials is focused on nanoporous surfaces, nanoparticles and gels. In the first case it was demonstrated that it is possible to engineering surfaces in terms of wetability, chemical composition and porosity to control cell adhesion [1]. Secondly, results further confirm that the interaction of nanoparticles with mammalian cells depends on their size, surface chemistry, dose, shape among many other experimental parameters [2]. Finally, recent advances in the synthesis of inorganic and hybrid gels for mammalian cell immobilization are presented. Particularly, results focused in the different characteristics of the gel required for adherent and non-adherent cells are discussed [3, 4]. The ability to control the structure of these materials from the nanoscale to the macroscale and the possibility to generate appropriate environments for living cells is one of the most important factors to be considered in the future. Acknowledgments: The author would like to acknowledge the support of grants from the University of Buenos Aires UBACYT 20020110100081 and from Agencia Nacional de Investigaciones Científicas y Técnicas BID 1728/OC-AR PICT 1783. M.F.D. thanks the Argentina-France MINCYT-ECOS-Sud (project A12S01) and CONICET-CNRS programs for financial support. References: [1] M. G. Bellino, S. Golbert, M. C. De Marzi, G. J. A. A. Soler-Illia and M. F. Desimone, Biomater. Sci., 2013, 1, 186?189. [2] A. M. Mebert, D. E. Camporotondi, M. L. Foglia, G. S. Alvarez, P. L. S. Orihuela, L. E. Diaz and M. F. Desimone, J. Biomater. Tissue Eng., 2013, 3, 108?121. [3] P. N. Catalano, N. S. Bourguignon, G. S. Alvarez, C. Libertun, L. E. Diaz, M. F. Desimone and V. Lux-Lantos, J. Mater. Chem., 2012, 22, 11681?11687. [4] M. F. Desimone, C. Helary, I. B. Rietveld, I. Bataille, G. Mosser, M. M. Giraud-Guille, J. Livage and T. Coradin, Acta Biomater., 2010, 6, 3998?4004.