b-cyclodextrin-conjugated hydrogels for ocular release of novel antibacterial N-allyl thiosemicarbazone.

GLISONI R, GARCÍA-FERNÁNDEZ M. J., PINO M, GUTKIND G, MOGLIONI A, ALVAREZ-LORENZO C, CONCHEIRO A, SOSNIK A

Alicante

Congreso; XI Congreso de la Sociedad Española de Farmacia Industrial y Galénica; 2013

Incorporation of the safe pharmaceutical excipient CD to hydrophilic networks can open novel possibilities of development networks suitable as ocular bandages or SCLs that can host therapeutic amounts of a novel TSC that displays a broad antibiotic spectrum. The systems engineered provided a well-controlled sustained release for at least two weeks. Moreover, they inhibited the growth of two prominent bacteria associated with ocular infections.