IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Endohtelins as modulatory neuropeptides of the cardiovascular function and water/sodium homeostasis in the central nervous system
Autor/es:
VATTA MS; HOPE S; PERFUME G; BIANCIOTTI LG; NABHEN S
Lugar:
BUENOS AIRES - ARGENTINA
Reunión:
Simposio; XXII CONGRESO LATINOAMERICANO Y 1RO IBEROAMERICANO DE CIENCIAS FISIOLÓGICAS; 2006
Institución organizadora:
SOCIEDAD ARGENTINA DE FISIOLOGIA
Resumen:
Endothelins (ETs) is a family of isopeptides (ET-1, ET-2 and ET-3) that is widely distributed in different tissues and cell types of mammals including humans. Their biological effects are mediated through well characterized G-protein coupled receptors named ETA and ETB that activate multiple signaling pathways. However different studies support the existence of atipic receptors (ETAX and ETBX) as well as a third receptor subtype named ETC. Although ETs are predominantly synthesized by endothelial cells, the ETs system (mRNA ETs and receptors) has been reported in the central nervous system, particularly in the hypothalamus where the expression of ETs and their receptor is very abundant. The hypothalamus is a relevant diencephalic center where catecholamines play an important role in the regulation of water and sodium homeostasis as well as the cardiovascular function. Furthermore, the presence of ETs has been reported in catecholaminergic neurons. Based of these findings we commenced studies regarding the interaction between ETs and noradrenergic neurotransmission in the hypothalamus in order to determine whether this interaction play a role in the modulation of the hypothalamic response. Our findings show that the interaction of ETs and noradrenergic transmission is involved in the increase of blood pressure when ETs are applied to the brain. Furthermore, recent studies performed in hypertensive animals suggest that ETs play a role in the development and /or maintenance of salt-dependent experimental hypertension.