Alterations in intermediate metabolism and aorta aorta morphology induced by zinc deficiency and/or high fat diet during growth

MEDINA, AGUSTINA; MORIONDO, MARISA; MENDES GARRIDO, FACUNDO; ARRANZ, CRISTINA; PÁEZ, DIAMELA; SCHREIER, LAURA; ELESGARAY, ROSANA; GIACOMAZI, JULIA; ZAGO, VALERIA; CANIFFI, CAROLINA; TOMAT, ANALÍA

CABA

Congreso; Reunión conjunta SAIC-SAI-AAFE-NANOMED; 2021

SAIC-SAI-AAFE-NANOMED

Introduction: Zinc deficiency can coexist with overweight and obesity during growth predisposing to metabolic disorders in adult life.Objective: To evaluate, in adult male rats, alterations in intermediate metabolism and aorta morphology induced by fetal and postnatal zinc deficiency and/or high fat diet during post weaning life. Methodology: Female Wistar rats received low (L:8ppm) or control (C:30ppm) zinc diets from pregnancy to offspring weaning. C male offspring continued with C(C) or HFD (60% of total calories) (CH) diets. L offspring were fed L(L) or L and HFD(LH) diets. At day 81, we determined blood oxidative stress, glucose tolerance test (GTT), lipid profile, plasmatic adiponectin levels and thoracic aorta morphology. Two way ANOVA, Bonferroni post-test, mean±SEM, *p