IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
capítulos de libros
Título:
Antimicrobial properties of s ilica modified nanoparticles
Autor/es:
CAMPOROTONDI DANIELA EDHIT; ML FOGLIA; ALVAREZ GS; ANDREA MATHILDE MEBERT; DÍAZ LUIS EDUARDO; THIBAUD CORADIN; DESIMONE MARTÍN FEDERICO
Libro:
Microbial pathogens and strategies for combating them: science, technology and education
Editorial:
FORMATEX
Referencias:
Año: 2013; p. 283 - 290
Resumen:
The ability of certain strains of bacteria
to withstand the effects of common antibiotics has led to find novel strategies for
the treatment of infections associated to antimicrobial resistance and biofilm development in affected patients. The use of
nanoparticles containing antibiotics
has demonstrated numerous adva
ntages. As the antib
iotic is held into the nanoparticle,
chemical composition and modifications on the NP?s surface enable to prolong, localize, target and have a protected drug
interaction with the diseased tissue. In this way, higher an
tibiotic concentrations are attained in the targeted cells,
managing to reduce the frequency of the dosages taken, reducing
the drug side effects and fluctu
ation in circulating levels,
improving the overall pharmacokinetics. A la
rge variety of nanomaterial
s for efficient antibiotic drug delivery have been
developed and their efficacy has been demonstrated. Due to high thermal and chemical stability, high surface area and
good biocompatibility, silica nanoparticles are a good option to deliver
drugs such as antibiotics. In this chapter, we will
give an overview about the use of nanosized silica particle
s and silica modified nanoparticles loaded with antimicrobial
agents for infection prevention and treatment.