IQUIMEFA   05518
INSTITUTO QUIMICA Y METABOLISMO DEL FARMACO
Unidad Ejecutora - UE
artículos
Título:
Mechanism of the antiproliferative action of limonene on a lymphoma cell line: Participation of nitric oxide
Autor/es:
MARIA GABRIELA MANUELE; MARIA LAURA BARREIRO ARCOS; ROBERTO DAVICINO; GRACIELA FERRARO; GRACIELA CREMASCHI; CLAUDIA ANESINI
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
Wiley-Blackwell
Referencias:
Año: 2009 vol. 23 p. 1011 - 1017
ISSN:
0951-418X
Resumen:
Previously limonene demonstrated antiproliferative action on a lymphoma cell line(BW5147).The objective of this study was to investigate the mechanism of the antiproliferative action of limonene on BW 5147 cells. The induction of apoptosis and arrest in cell cycle phases, both phenomena related to nitric oxide (NO) production, were analyzed as well as NO production. Results showed that limonene exhibited antiproliferative action on tumoral lymphocytes exerting a decrease in cell viability that was related to apoptosis induction and to the increase in NO levels at long times of incubation. At short times and depending on its concentration, limonene arrested cells in different phases of the cell cycle, related to NO production.